Apoptosis, Cell Death and Inflammation
Editor: Véronique Witko-Sarsat (veronique.witko@inserm.fr)

In this issue, apoptosis of inflammatory cells and their subsequent clearance by professional phagocytes or by bystander cells, will be discussed. This is a key event in the resolution of inflammation. For instance, the life span of neutrophils must be strictly regulated. Delayed neutrophil apoptosis is beneficial for pathogen elimination while apoptosis on the other hand is necessary to prevent release of cytotoxic content from activated neutrophils at sites of inflammation. Interestingly, apoptosis of inflammatory cells can be triggered and in other ways modulated by pathogens, which add another level of complexity to the regulation of apoptosis. Recognition of apoptotic cells by macrophages triggers an anti-inflammatory response. The ability of macrophages to recognize ligands on apoptotic cells, respond appropriately, and engulf these cells is an important event in host defence, which could predispose to development of autoimmunity if dysregulated. Engulfment of apoptotic cells by macrophages, also called "efferocytosis", is a process that confers an anti-inflammatory phenotype to macrophages conducing to resolution of inflammation. http://www.karger.com/jin

Invitation for papers
The editors invite the submission of original articles, short communications, mini reviews, and letters to the editors. Manuscripts written in English should be submitted using the online submission website at
http://www.karger.com/jin Criteria for acceptance are quality, originality, and clarity. The Journal of Innate Immunity will not consider papers that are either preliminary or purely descriptive. Reports on clinical cases are accepted only if they provide novel insight into unresolved problems of innate immunity. Should you experience any problems with your submission, please contact the Editorial Office.

Editors-in-Chief
Heiko Herwald Lund
Arne Egesten Lund


Editorial Board
B. Beutler, La Jolla, Calif.
G.M. Bokoch, La Jolla, Calif.
N. Borregaard, Copenhagen
G.D. Brown, Cape Town
E. Crouch, St. Louis, Mo.
B. Dahlbäck, Malmö
S. Gordon, Oxford
J. Hoffmann, Strasbourg
M. Hornef, Hannover
T. Kaisho, Yokohama City
J.D. Lambeth, Atlanta, Ga.
G. McFadden, Gainsville, Fla.
E. Medina, Braunschweig
P.M. Murphy, Bethesda, Md.
V. Nizet, La Jolla, Calif.
J.E. Pease, London
J. Potempa, Athens, Ga.
C.S. Reiss, New York, N.Y.
J.A. Russell, Vancouver, B.C.
D. Schneider, Stanford, Calif.
J.-M. Schröder, Kiel
C. Speth, Innsbruck
A.N. Theofilopoulos, La Jolla, Calif.
U. Theopold, Stockholm
J.A.G. van Strijp, Utrecht
M.A. Williams, Rochester, N.Y.
V. Witko Sarsat, Paris
M.A. Zasloff, Washington, D.C.